Results of modeling of pharmaceuticals mixtures toxicity with deviation ratio and best-fit functions models using Saccharomyces cerevisiae yeast as model organism

The research was concerned with verifying the impact of binary mixtures of nine pharmaceuticals against a selected organism, i.e., the yeast Saccharomyces cerevisiae. S cerevisiae is used as a model organism in the monitoring of endocrine disruptors in environmental and reference samples in Xenometrix® systems - XenoScreen®.  Tested pharmaceuticals, namely: diclofenac (sodium salt), oxytetracycline, hydrochloride, fluoxetine hydrochloride, chloramphenicol, ketoprofen, progesterone, estrone, androstenedione and gemfibrozil, are widely used in various therapeutic treatments. To investigate endocrine potential of mixture of drugs slightly modified protocol of XenoScreen YES/YAS® was utilized, which uses genetically modified yeast cells of Saccharomyces cerevisiae.Studies were conducted between 2015.These results are part of the manuscript published in Science of the Total Environment (https://doi.org/10.1016/j.scitotenv.2016.07.186)