MUC1, MUC4, Stn, TN dataset in cervical cancer

The photomicrographs are images of immunohistochemically stained cervical cancer and lymph node metastases. The specimens were prospectively collected from patients enrolled in the Gynecologic Oncology Group (GOG) clinical trial GOG0221: Glycoprotein and glycan profiling in patients with locally advanced cervical cancer (Stage IB2, IIA > 4 cm, IIB to IVA) undergoing pelvic and para-aortic (abdominal) lymphadenectomy (clinicaltrials.gov:NCT00460356). Sections of the specimens immunohistochemically stained for mucin 1 and 4 proteins (MUC1 and MUC4, respectively) and Sialyl Tn (STn) and Tn antigens were reviewed by experienced gynecologic pathologists and areas of interest for photomicrography were selected by the first two authors of this brief (R.R. and R.C.). Representative images for all immunohistochemical stains showing their expression patterns as well as positive and negative controls were shown and described.

本数据集包含了免疫组化染色的宫颈癌和淋巴结转移的显微照片。样本系前瞻性收集自参与妇科肿瘤学组（Gynecologic Oncology Group，简称GOG）临床试验GOG0221的患者，该试验旨在研究局部晚期宫颈癌（分期为IB2、IIA > 4 cm、IIB至IVA）患者在盆腔和腹主动脉（腹部）淋巴结清扫术（临床注册号：clinicaltrials.gov:NCT00460356）过程中糖蛋白和糖类分析。样本经免疫组化染色以检测粘蛋白1和4蛋白（MUC1和MUC4）以及唾液酸化Tn（STn）和Tn抗原，并由经验丰富的妇科病理学家进行审查。本简报的前两位作者（R.R.和R.C.）挑选了显微照片感兴趣的区域。展示了所有免疫组化染色的代表性图像，并描述了其表达模式和阳性、阴性对照。