Supplemental Tables for Nicotine use, obesity, and vitamin D deficiency predict acute complications of excisional dermatologic surgery: An international, propensity-matched retrospective cohort study

These tables contain the relevant diagnostic codes used in the study.

Abstract
Background: Postoperative complications from dermatologic surgeries lead to patient morbidity and increased healthcare costs. Identifying patient-specific risk factors may improve outcomes.
Objective: Evaluate risk factors for dermatologic surgery complications while controlling for confounding variables.
Methods: This retrospective cohort study utilized the international TriNetX database, which included data from approximately 930,000 patients undergoing excisional dermatologic surgery (Mohs micrographic surgery, malignant excisions, benign excisions). Propensity scoring balanced cohorts on a wide range of conditions and medications. Logistic regressions evaluated patient characteristics and 30-day complication rates.
Results: The overall complication rate was low (1.7%). Nicotine use, obesity, anticoagulants (e.g., warfarin, apixaban, heparin), and antiplatelets (e.g., aspirin, clopidogrel, ticagrelor) predicted complications. Vitamin D deficiency and oral corticosteroid use predicted infection and dehiscence. Oral small molecules (methotrexate, azathioprine, mycophenolate, cyclosporine, tacrolimus, sirolimus, and everolimus) showed no association with complications. Poorly controlled DM or HTN predicted greater risks of complications relative to well-controlled diabetes and hypertension.
Limitations: Retrospective design, potential under-recording of complications, acute complications only, and lack of tumor- and site-specific information.
Conclusion: Modifiable risk factors, including nicotine use, obesity, vitamin D deficiency, and poorly controlled diabetes or hypertension, predict complications. Considering these factors preoperatively and postoperatively could improve dermatologic surgery outcomes.