Data from: Anthracycline drugs on modified surface of quercetin-loaded polymer nanoparticles: a dual drug delivery model for cancer treatment

Polymer nanoparticles are vehicles used for delivery of hydrophobic
anti-cancer drugs, like doxorubicin, paclitaxel or chemopreventors like
quercetin (Q). The present study deals with the synthesis and
characterisation of nano formulations (NFs) from Q loaded PLGA (poly
lactic-co-glycolic acid) nano particles (NPs) by surface modification. The
surface of Q-loaded (NPs) is modified by coating with biopolymers like
bovine serum albumin (BSA) or histones (His). Conventional
chemotherapeutic drugs adriamycin (ADR) and mitoxantrone (MTX) are bound
to BSA and His respectively before being coated on Q-loaded NPs to nano
formulate NF1 and NF2 respectively. The sizes of these NFs are in the
range 400-500 nm as ascertained by SEM and DLS measurements. Encapsulation
of Q in polymer NPs is confirmed from shifts in FT-IR, TGA and DSC traces
of Q-loaded NPs compared to native PLGA and Q. Surface modification in NFs
is evidenced by three distinct regions in their TEM images; the core,
polymer capsule and the coated surface. Negative zeta potential of
Q-loaded NPs shifted to positive potential on surface modification in NF1
and NF2. In vitro release of Q from the NFs lasted up to twenty days with
an early burst release. NF2 is better formulation than NF1 as loading of
MTX is 85% compared to 23% loading of ADR. Such NFs are expected to
overcome multi-drug resistance (MDR) by reaching and treating the target
cancerous cells by virtue of size, charge and retention.