Salivary microbiome associated with inflammatory bowel diseases. human oral metagenome

Since accumulated knowledge has indicated the noteworthy role of oral microbiota in various systemic diseases, here, we hypothesized the existence of dissonant structure, composition and function of oral microbiota and different community types associated with IBD, and explored oral indicators potentially available for predicting the disease. We examined the V3–V4 region of 16S rRNA gene of the salivary bacterial DNA from 54 ulcerative colitis (UC), 13 Crohn’s disease (CD) and 25 truly healthy individuals using Illumina sequencing platform.