Primary analysis: SNPs that showed genome-wide associations (p≤1.0×10−5) with CAC in GENOA (smokers, nonsmokers, gene×smoking interactions).

In addition, GENOA SNPs located in genes that are related to CAC with p-values between 10−4 and 10−5 are shown (used in secondary analysis). The corresponding Framingham p values for GENOA index SNP are presented.SNP, single nucleotide polymorphism; Chr, chromosome; Mb, megabases; MAF, minor allele frequency; Beta, beta coefficient; SE, standard error. Models were adjusted for the following covariates: age, sex, body mass index (BMI), pulse pressure, diabetes, systolic blood pressure (SBP), use of anti-hypertensive medications, use of lipid lowering medications, and LDL-cholesterol.