Area under the curve across different models.

BackgroundSeptic shock is a life-threatening condition that requires rapid assessment to reduce mortality. This study investigated the relationship between the blood pressure response index at admission and short-term mortality in septic shock patients.MethodsWe retrospectively analyzed clinical data from the MIMIC-IV database via multivariable logistic regression, sensitivity analysis, and restricted cubic spline models to explore the associations between the BPRI at ICU admission and short-term mortality. Kaplan-Meier estimates and ROC curves evaluated BPRI’s predictive value.ResultsIn 7,382 patients, a higher BPRI was linked to reduced short-term mortality. Each standard deviation increase in the BPRI led to 2.5%, 2.0%, and 1.8% reductions in in-hospital, 28-day, and 90-day mortality, respectively. K‒M analysis revealed significantly lower short-term mortality in patients with higher BPRIs (P ConclusionAn elevated BPRI at ICU admission is significantly associated with reduced short-term mortality in septic shock patients, indicating its potential as an early prognostic tool for risk assessment.