Antigen-specific CD8+ T cell transcriptome and splicing changes after costimulation in vivo [CRISPR]
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https://www.ncbi.nlm.nih.gov/sra/SRP367696
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资源简介：
Here we provide a dataset of deep RNA sequencing from mouse CD8+ T cell CRISPR-mediated knockout of RBP Tardbp after adoptive transfer and antigen+costimulatory stimulus (in mice) which we show is critical for optimal CD8+ T effector function. Overall design: 2 groups: adoptively transferred Control gRNA CRISPR CD8+ T cells, adoptively transferred Tardbp gRNA CRISPR CD8+ T cells ; both groups received antigen (SIINFEKL) + costimulation (anti-OX40, anti-41BB)
创建时间：
2022-07-01
