Salmonella Typhimurium infect murine macrophages

Salmonella enterica serovar Typhimurium (S. Typhimurium), an intracellular pathogen responsible for severe diseases in mammalian hosts, triggers robust innate immune responses in macrophages. Furthermore, Salmonella infection induces host metabolic reprogramming, transitioning from oxidative phosphorylation to glycolysis, reminiscent of the Warburg effect. In this context, the use of glycolysis inhibitors affects S. Typhimurium infection in macrophages.