Sneyd1995_CalciumWave_IP3diffusion

This a model from the article:
Intercellular calcium waves mediated by diffusion of inositol trisphosphate: a
two-dimensional model.

Sneyd J, Wetton BT, Charles AC, Sanderson MJ. Am J Physiol
1995 Jun;268(6 Pt 1):C1537-45 7611375
,
Abstract:

In response to mechanical stimulation of a single cell, airway epithelial cells
in culture exhibit a wave of increased intracellular free Ca2+ concentration
that spreads from cell to cell over a limited distance through the culture. We
present a detailed analysis of the intercellular wave in a two-dimensional sheet
of cells. The model is based on the hypothesis that the wave is the result of
diffusion of inositol trisphosphate (IP3) from the stimulated cell. The
two-dimensional model agrees well with experimental data and makes the following
quantitative predictions: as the distance from the stimulated cells increases,
1) the intercellular delay increases exponentially, 2) the intracellular wave
speed decreases exponentially, and 3) the arrival time increases exponentially.
Furthermore, 4) a proportion of the cells at the periphery of the response will
exhibit waves of decreased amplitude, 5) the intercellular membrane permeability
to IP3 must be approximately 2 microns/s or greater, and 6) the ratio of the
maximum concentration of IP3 in the stimulated cell to the Km of the IP3
receptor (with respect to IP3) must be approximately 300 or greater. These
predictions constitute a rigorous test of the hypothesis that the intercellular
Ca2+ waves are mediated by IP3 diffusion.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Sneyd J, Wetton BT, Charles AC, Sanderson MJ. (1995) - version=1.0

The original CellML model was created by:
Wei Liu

[e-mail]
The University of Auckland
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