Haplotype analysis of HIVEP1 haplotypes derived from rs169713, rs169715 and rs2228220 in a sample of 1,542 cases and 1,110 controls.

HIVEP1 haplotypes were strongly associated with VT risk (χ2 = 30.22 with 5df, p = 1.33 10−5).All haplotypes carrying the rs169715-G or the rs2228220-G alleles tended to be more frequent in cases than in controls, suggesting that both alleles could act additively to influence VT risk. This hypothesis were then tested and was not rejected (χ2 = 0.75 with 2 df, p = 0.686). After adjusting for rs2228220, the OR associated with the rs169715-G allele was 1.57 [1.17–2.09] (p = 2.60 10−3) and the OR associated with rs2228220-G adjusted for rs169715 was 1.35 [1.10–1.66] (p = 3.98 10−3). After adjusting for these two SNPs, the rs169713-C allele was not significant (OR = 1.11 [0.97–1.26], p = 0.129).