Prrx1 fibroblasts represent a pro-fibrotic lineage in the mouse ventral dermis
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
Skin scarring following dermal injury causes extreme pain and pschological trauma for patients. Currently, we do not have effective treatments to prevent or reverse skin scarring. Fibroblast heterogeneity has been shown within the unwounded mouse dorsal dermis, with fibroblast subpopulations being identified according to anatomical location and embryonic lineage. Using RNA-sequencing and single cell RNA sequencing, we demonstrate that Prrx1-expressing mouse fibroblasts are responsible for acute and chronic scaring in the ventral mouse dermis. In summary, we have identified and characterized a fibroblast subpopulation in the mouse ventral dermis with intrinsic scar-forming potential.
提供机构：
Stanford University
创建时间：
2022-02-20
