Expression QTLs colocalized with psoriasis GWAS SNPs.

Matrix columns correspond to eQTLs from different tissue/cell types. Matrix rows correspond to psoriasis GWAS SNPs that showed strong evidence (Posterior Probability, PP4 ≥ 0.8) for colocalization with a given eQTL at a given row. Each matrix cell contains a gene name for the affected gene and a Beta-value. Beta-value has a positive or negative value depending on whether the eQTL effect allele increases or decreases gene expression. For example, consider the cell entry, “ZMIZ1 +0.290125”, at the intersection of the first line, “chr10_79283816_A_G”, and the column “Schmiedel_2018*NK-cell_naive_ge”. Here, the G allele for eQTL chr10_79283816_A_G increases the expression of the ZMIZ1 gene in naive NK-cells (Schmiedel_2018*NK-cell_naive_ge) proportional to Beta = +0.290125 relative to the alternative A allele. (XLSX)