Removal of Reaction Solvent by Extractive Workup: Survey of Water and Solvent Co-extraction in Various Systems

In some chemical processes, extractive workup is used to remove
the solvent of reaction in an aqueous layer and to isolate the
product in the organic layer. Most of the time some reaction
solvent is co-extracted in the organic layer, along with some
water. This has a non-negligible impact on subsequent operations (washing, crystallization), and we have thus determined
those levels for ten reaction solvents and five extraction solvents
in order to help the process chemist in the development of
efficient isolation procedures.