Co-localization of QTLs for biomechanics, BMD, bone size, BMC, cortical and trabecular bone traits of tibia in GKxF344 F2 rats.

M = QTL detected in males; F = QTL detected in females; Cr1 = Cross 1 (GK mtDNA); Cr2 = Cross 2 (F344 mtDNA). QTLs linked to 3D-CT and pQCT phenotypes are reported in references [23], [24]. fFemale-specific QTL; cCross-specific QTL. The strongest linkage detected in either sex or reciprocal cross is marked in bold. CAmid = Cortical area at midshaft (mm2); CortBMC = cortical mineral content (mg/mm); CortBV = Cortical bone volume (mm3); CortvBMD = cortical volumetric BMD (g/cm3); CSA = Cross-sectional area (mm2); EAfib = Endosteal area at fibula-site (mm2); EC = Endosteal circumference (mm); IP = Moment of inertia (mm4); MetavBMD = metaphyseal volumetric BMD (g/cm3); PAfib = Periosteal area at fibula-site (mm2); PAmid = Periosteal area at midshaft (mm2); PC = Periosteal circumference (mm); RP = Moment of resistance (mm3); TotBMC = total bone mineral content (mg/mm); TotBV = Total bone volume (mm3).