Reduced sialylation triggers complement c3-mediated neuronal loss in aging mice

ChEBI2019-10-07 更新2026-07-12 收录

神经退行性机制

衰老生物学

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Reduced sialylation triggers complement c3-mediated neuronal loss in aging mice

创建时间：

2019-10-07

Examination of gene expression in cerebellum and hippocampus for mouse C57BL/6J WT and nmf205-/-

神经退行性机制

细胞应激通路

Ribosome stalling during translation has recently been shown to cause neurodegeneration, yet the signaling pathways triggered by stalled elongation complexes are unknown. To investigate these pathw

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AAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS Neurons. AAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS Neurons

神经退行性机制

功能障碍研究

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

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Synaptic vesicle proteomics with age and in synucleinopathies

突触小泡蛋白质组学

神经退行性机制

Neurotransmitter release occurs through exocytosis of synaptic vesicles. α-Synuclein’s function and dysfunction in Parkinson’s disease and other synucleinopathies is tightly linked to synaptic vesicle

NIAID Data Ecosystem20

Imaging resident and recruited macrophage contributions to Wallerian degeneration. Imaging resident and recruited macrophage contributions to Wallerian degeneration

神经退行性机制

巨噬细胞功能组学

Abstract: Wallerian degeneration (WD) is a process of autonomous distal degeneration of axons upon injury. Macrophages (MP) of the peripheral nervous system (PNS) are main cellular agent controlling t

NIAID Data Ecosystem100

In Vitro Modeling of Age-Related Methylation Changes with Intestinal Organoids [RNA-Seq]

衰老生物学

表观遗传学

Intestinal organoids, three-dimensional cultures from intestinal stem cells, are a powerful model for studying aging, and DNA methylation is an accurate biological clock. Consequently, we hypothesized

NIAID Data Ecosystem20

Reduced sialylation triggers complement c3-mediated neuronal loss in aging mice

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