S1 Data consists of three Excel files, each containing different aspects of the drug information related to the treatment of angina: DDFA File contains data on 94 single drugs used for the treatment of angina.

110 Combination Drugs File includes 110 synergistic drug combinations, each formed by pairing the 94 single drugs from the DDFA file. These combinations have been validated for their therapeutic efficacy in treating angina. The Target and the Pathway of Target Action File provides detailed information about the molecular targets and associated pathways of action for each of the 94 single drugs in the DDFA file. (ZIP)