FOXM1 variant contributes to gefitinib resistance via activating wnt/ß-catenin signal pathway in non-small cell lung cancer patients

To further explore the functional role of rs3742076 in the regulation of gefitinib response, stable overexpression FOXM1 rs3742076_A and _G were established in PC9 cells in which FOXM1 knock-out by CRISPR/Cas9. Overall design: Differentially expressed genes were identified from transcriptome analysis between FOXM1 rs3742076_A and rs3742076_G cells Comparative gene expression profiling analysis of RNA-seq data for FOXM1 rs3742076_A cells and rs3742076_G cells.