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ReactIR Monitoring of Turbo-Hauser Base Formation Enables a Robust Iodination Reaction During an Early Scale-Up Campaign

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NIAID Data Ecosystem2026-05-10 收录
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https://figshare.com/articles/dataset/ReactIR_Monitoring_of_Turbo-Hauser_Base_Formation_Enables_a_Robust_Iodination_Reaction_During_an_Early_Scale-Up_Campaign/31888497
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We required a robust, reliable method to form the Turbo-Hauser base TMPMgCl·LiCl during an early scale-up campaign to support the synthesis of key intermediate 1 within our Discovery Process team. We report herein our investigations with ReactIR and kinetic modeling to better understand the formation of the Turbo-Hauser base on scale, resulting in the successful application of our optimized protocol to enable the preparation of the target building block on the decagram scale.
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2026-03-30
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