Testing for COVID-19 in High Risk Children with Intellectual and Developmental Disabilities (COV-IDD)

Project Goals:
1) Virological Testing: We will establish a nasal-swab FDA-approved testing regimen to monitor and identify disease outbreaks in a specialized school setting serving 450 children with moderate-to-severe IDD and the 500 staff supporting them, a setting at ultra-high risk for COVID-19 disease transmission. We will rapidly identify infections and develop approaches for isolating and contact-tracing to stem virus spread.
2)Serological Testing: Serology will establish background immunity levels in students and staff, from infection or vaccination, and will follow those who are antibody-positive longitudinally to quantify temporal decay of IgG and neutralizing antibody levels. We will determine whether protective immunity in children with IDD, a population with prevalent immunological dysfunction, wanes at an accelerated rate compared to the population-at-large; by doing so we will address an important knowledge gap, and provide key data to inform public health policy.
3) Modeling to Optimize Testing: We will use network models and agent based simulation models (or hybrid approaches) to guide testing strategies and interventions at MCC. Simulations will be conducted interactively and iteratively, to assist in planning and implementation of testing procedures, exploring the dynamic interplay between school operations and personnel interactions, potential infection risks and disease dynamics (including variant strains), and implementation of control measures (e.g. quarantine, isolation, contact-tracing and vaccination rates).
4) Mobile Unit Testing: We build on our successful mobile approach to delivering mobile dental care to the IDD students of MCC (the SMILEmobile), by staffing, equipping and deploying a customized, disability-enabled, mobile testing unit. We will use this to directly deliver rapid flexible testing to MCC.
5) Overcoming Testing & Vaccine Anxiety/Hesitancy: We will conduct focus group interviews at MCC to identify key community concerns,myths and misconceptions about vaccination, and we will then build on our success in reducing vaccine hesitancy among URMC staff, to create a multimodal educational campaign that addresses these concerns. Strategies will include a speakers’ bureau, group discussions, and “table talk” conversations, combined with innovative visual approaches that communicate complex information in a readily accessible manner (via graphic medicine) and that promote vaccine uptake (via narrative portraits of trusted peers and coworkers who have chosen to be vaccinated). Finally, we will assess the impact of this program by deploying a validated, electronic patient reported outcome scale (PROMIS-29) already in widespread use across the UR health system and at Rochester’s East High School, to collect longitudinal data from staff, parents/guardians and children (by proxy reporting) across multiple health domains (including anxiety, depression, sleep disturbance, and social functioning). This scalable approach will reveal the full impact of the interventions and approaches proposed, and is readily compatible with extension to other sites in the RADx network.