Gene expression profiling of MYC inducible murine tumor models (tissues) [microarray]

The transcription factor, c-MYC, is a proto-oncogene that is activated in many types of cancer. To study how MYC promotes and maintains the neoplastic phenotype, we use tetracycline-regulated systems in transgenic mice whereby we can conditionally activate MYC. We profile the changes in gene expression when MYC is activated versus inactivated in order to identify a gene signature that is associated with the ability of MYC to promote tumorigenesis. Total RNA was obtained from mouse tumors, driven by the activation of MYC (or another oncogene), as well as from the tissue of control FVB/N mice.