A clinically transferable MICA–SRGN immune-anchor readout links immune-state stratification to interface remodeling in epicardial adipose tissue in HFpEF

Background: Interface-centered pathology is increasingly recognized as an important mechanistic layer in HFpEF, yet its tissue-level organization remains insufficiently resolved. In epicardial adipose tissue (EAT), it is unclear whether disease relevance reflects a uniform depot-wide shift or a compartment-restricted pathological niche. Methods: We used a staged human tissue translation framework integrating colocalization-guided gene prioritization, paired tissue mapping, bulk transfer testing, and HFpEF-oriented downstream interpretation... Results: Paired EAT–RAA mapping showed that prioritized genes did not form a uniformly EAT-upregulated program, but instead localized in a compartment-specific manner, supporting a selectively remodeled... Conclusions: Disease-relevant EAT biology is better interpreted as a compartment-restricted, immune-interface–leaning component with predominant stromal/interface coupling rather than a uniformly shifted bulk adipose program. We define .. This Zenodo record contains processed datasets and selective figure source data supporting the conclusions of the associated manuscript. Publicly available datasets analyzed in this study were obtained from external repositories, including GEO accession numbers GSE192886, GSE263154, and GSE64554, and GWAS Catalog accession numbers GCST90572772 and GCST90728697, as described in the manuscript. The files deposited here correspond to processed results generated during the study. Analysis scripts are archived separately in a GitHub-linked repository and will be provided to the publisher and reviewers via DOI. This deposition was submitted by Ge Yuan and Shi Q on behalf of the research team.