Systematic assessment of Hi-C data quality control software and the development of the Motif-Hi-C rapid data quality control method

High-throughput chromatin conformation capture technology (Hi-C) is currently the most widely applied technology in three-dimensional genomics research. However, there are few comprehensive evaluations reported on mainstream Hi-C data quality control software, and there are also significant differences in the specific analysis processes and strategies of different software, leading to limitations in their application.