Estimated ranges for parameter values based on previous experimental and computational studies.

Rates for endogenous mRNA degradation (norm) and ribozyme cleavage (rib) are separately described. αReflects the time to reach the termination stem following transcription initiation and is dependent on the rate of polymerase extension, pausing, the length of the transcribed sequence, and nucleotide concentration. βIncludes mRNA or protein degradation and dilution due to cell division. γObserved upper limit.