Gene expression data from the hippocampus of rats with prenatal valproic acid exposure

Comparative analyses revealed that prenatal VPA exposure altered gene expression, a part of which is involved in key features including memory, developmental process, and epilepsy. Oxytocin partly improved these gene expression, which were predicted to interact with those involved in social behaviors and hippocampal-dependent memory. The present study documented molecular profiling in the hippocampus related to ASD and improvement by chronic treatment of oxytocin.比较分析结果显示，产前丙戊酸（VPA）暴露可改变基因表达谱，其中部分基因与记忆、发育进程及癫痫等关键特征相关。催产素可部分改善此类基因表达；经预测，该类基因可与参与社交行为及海马依赖型记忆的基因产生相互作用。本研究记录了与自闭症谱系障碍（ASD）相关的海马体分子谱特征，以及催产素慢性给药干预所带来的改善效果。