BindingDB Entry 50018907: Profile and molecular modeling of 3-(indole-3-yl)-4-(3,4,5-trimethoxyphenyl)-1 H-pyrrole-2,5-dione (1) as a highly selective VEGF-R2/3 inhibitor.

Small molecule binding data for protein AKT/p21CIP1, Aurora kinase B/Inner centromere protein, CDK2/Cyclin A/Cyclin A1, Cyclin-Dependent Kinase 4 (CDK4), Ephrin type-B receptor 4 (EphB4), Epidermal growth factor receptor, Epidermal growth factor receptor and ErbB2 (HER1 and HER2), Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Glycogen synthase kinase-3, Insulin receptor, Insulin-like growth factor I receptor, Platelet-derived growth factor receptor beta, Serine/threonine-protein kinase Aurora, Serine/threonine-protein kinase Nek2, Serine/threonine-protein kinase PLK1, Tyrosine-protein kinase ABL1, VEGF-receptor 2 and tyrosine-protein kinase SRC, Vascular endothelial growth factor receptor 2, and Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), Uniprot O14965, P00519, P00533, P04626, P06213, P08069, P09619, P11802, P12931, P20248, P24385, P24941, P31749, P35916, P35968, P49841, P51955, P53350, P54760, P78396, Q02763, Q05397, Q541P7, and Q96GD4