The present study investigates potential associations of murine PTPN22 genotype to severity of induced DSS colitis, with a particular focus on the murine gut microbiota.
Crystal structure of human tyrosine phosphatase PTPN22 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Tyrosine-protein phosphatase non-receptor type 22 Authors: Ugochukwu, E, Salah, E, Barr, A, Shrestha, L
Obstructive chronic lung allograft dysfunction (BOS) is the major limiting factor for lung transplantation (LTx) outcome. PTPN22 is described as the hallmark autoimmunity gene, and one specific single
Protein tyrosine phosphatase PTPN22 (LYP, PEP) dephosphorylates ZAP70 adaptor protein on tyrosine residue Y493, resulting in reduced activation of ZAP70. Dephosphorylation of ZAP70 contributes to PTPN
The present study investigates potential associations of murine PTPN22 genotype to severity of induced DSS colitis, with a particular focus on the murine gut microbiota.