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BCL6 represents a therapeutic target in E2A-PBX1 and MLL-rearranged acute lymphoblastic leukemia

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NIAID Data Ecosystem2026-03-14 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE59541
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We used ChIPseq to identify target genes of BCL6 that are involved in leukemogenesis of E2A-PBX1 and MLL-AF4 pre-B ALL. ChIP-seq using BCL6 antibodies in RCH-ACV and ICN12 (E2A-PBX1 acute lymphomablastic leukemia), RS4;11, SEM and ICN13 cells (MLL-AF4 rearranged acute lymphomablastic leukemia), and LAX7R cells (relapsed acute lymphomablastic leukemia with KRAS-G12V mutation).
创建时间:
2022-11-29
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