Processed data and MATLAB code for social compatibility study in sleep-disrupted rodents

Social compatibility in opposite-sex prairie vole pairs is modulated by early-life sleep experienceLezio S. Bueno-Junior 1*, Noah E. P. Milman 2,3, Carolyn E. Jones-Tinsley 2,3, Anjesh Ghimire 1, Peyton T. Wickham 2,3, Yujia Hu 4,5, Bing Ye 4, Miranda M. Lim 2,3, Brendon O. Watson 1*1 Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, USA2 Portland VA Research Foundation, Portland, OR, USA3 Department of Neurology, Oregon Health and Science University, Portland, OR, USA4 Life Sciences Institute and Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA5 Cleveland Clinic Research, Cleveland, OH, USA*Correspondence: Lezio S. Bueno-Junior ([e-mail]), Brendon O. Watson ([e-mail])AbstractStudies of human social behavior indicate stronger social affinity in matched-neurotype dyads (e.g., two individuals with autism or two without) compared to mixed-neurotype dyads (e.g., one individual with autism paired with one without). Is this dyad matching phenomenon also quantifiable in non-human animals? Using deep learning tools, we analyzed dyadic male-female interactions in prairie voles, a socially monogamous rodent species. To simulate “neurotypes”, voles were exposed to either control conditions or early-life sleep disruption (ELSD) during a critical neurodevelopmental period (postnatal days 14-21), recapitulating the influence of developmental sleep quality on later-life social behavior. Analogous to human studies, voles showed signs of reduced social affinity in mixed dyads compared to matched dyads, including sex-specific changes in aggression and body orientation toward the conspecific. These findings advance our understanding of social affinity between potential partners, providing a framework for new studies in both animal models and humans.