Expression cloning of the murine and human interleukin 9 receptor cDNAs.
收藏PubMed Central1992-06-15 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC49358/
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资源简介：
Interleukin 9 (IL-9) is a T-cell-derived lymphokine that induces the proliferation of various lymphoid and hemopoietic cells. A cDNA clone encoding the murine IL-9 receptor was isolated by expression cloning in COS cells and screening with 125I-labeled IL-9. Transient expression of this cDNA produced high-affinity binding sites for IL-9. The predicted 52-kDa protein contains a putative signal peptide and a typical transmembrane domain. A cDNA for the human homologue was isolated by cross-hybridization. Transfection of this cDNA in a murine T-cell clone conferred responsiveness to human IL-9. Sequence analysis revealed that the IL-9 receptor belongs to the recently described hematopoietin receptor super-family and is expressed in membrane-bound and soluble forms. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1992-06-15
