APL1A alleles display distinct protective function against P. falciparum infection.

(1)Chi-square p-value comparing GFPkd versus APL1Akd for each experiment (EXP.).(2)For each allele, the p-value of the 3 experiments were combined by meta-analysis.This table presents the results from three independent APL1A gene-silencing assays (shown in Figure 4). From each mosquito both APL1A alleles were determined using the APL1A-RFLP test. For each gene-silencing treatment (GFPkd or APL1Akd) and for each experiment (EXP.), the oocyst infection prevalence (Inf. Prevalence) is given. The column labeled (n) indicates the sum of the corresponding APL1A allele in the mosquitoes of the experiment. Significance was calculated by Chi-square analysis, comparing the infection prevalence between GFPkd and APL1Akd mosquitoes for each experiment and for each allele (APL1A1, APL1A2, APL1A3). A meta-analysis using the Fisher method was also used to combine p-values of the three independent experiments.