Supplementary Material for: Gastrointestinal Symptom-Free Multiple Lymphomatous Polyposis: An Atypical Case Presentation of Mantle Cell Lymphoma

Introduction: Mantle cell lymphoma (MCL), a rare Non-Hodgkin's Lymphoma, exhibits a genetic translocation causing CCND1 gene overexpression, affecting 5% of NHL cases, predominantly in males aged 60-70. Typically diagnosed with advanced symptoms, MCL involves widespread disease and organ spread, being aggressive and incurable with a 1.8 to 9.4-year average survival. Optimal treatment depends on disease aggressiveness and age. Multiple lymphomatous polyposis (MLP), a rare MCL subtype in the GI tract, usually presents with GI symptoms. Case Presentation: A 71-year-old woman diagnosed with asymptomatic MLP during MCL staging who underwent thoracentesis and was treated with a chemotherapy regimen of Rituximab/Cytarabine (r-AraC) and later transitioned to Bendamustine/Rituximab. This patient eventually underwent a bone marrow biopsy and later a bone marrow transplant. Conclusion: We present a unique case of asymptomatic MLP, emphasizing the importance of early detection for the poor prognosis of MLP with a mean survival of less than 3 years.