Sus scrofa breed:Large White Raw sequence reads. Sus scrofa breed:Large White

Diarrhea is one of the most common diseases in pig industry, which seriously threatens the health of piglets and causes huge economic losses. Enterotoxigenic Escherichia coli (ETEC) F4 is regarded as the most important cause of diarrhea in piglets. Some pigs are naturally resistant to those diarrheas caused by ETEC-F4, because they have no F4 receptors (F4R) on their small intestine epithelial cells that allow F4 fimbriae adhesion.In our previous study, we identified the association between ITGB5 and ETEC F4ac susceptibility.Combining the results of cell adhesion assay and ITGB5 genotyping, four pigs with adhesive small intestine epithelial cells with TT genotype were selected as the adhesive group, and another four pigs with non-adhesive small intestine epithelial cells with CC genotype were selected as the non-adhesive group.The total RNA was extracted from small intestine tissues of eight selected piglets for RNA sequencing.