Effects of LpxC and lpxD disruption on Acinetobacter baumannii and phage interactions

LpxC and lpxD are involved in the synthesis of bacterial LPS and are essential for the maintenance of bacterial outer membrane integrity.Here, we show that loss of lpxC and lpxD affects energy metabolism in A. baumannii and is associated with bacterial-phage interactions.The lpxC and lpxD deficient strains showed significantly different changes compared with the parental strain under phage pressure. RNAseq profiles of ATCC19606, lpxC and lpxD knockout strains and their exposure to phage stress