HUVEC molQTL resource: bulk RNA-seq QTL summary statistics (GRCh38)

Bulk RNA-seq QTL summary statistics If you use this dataset, please cite the manuscript in order to fairly acknowledge the contribution of all participating studies and their sponsors. Study overview This repository provides access to bulk RNA-seq quantitative trait loci GWAS summary statistics generated in the study: Dissecting the Cellular Genetics of Cardiovascular Disease Through Endothelial and Immune Compartments ProfilingStephen Watt, Matiss Ozols, Arianna Landini, Bin Liu, Sodbo Sharapov, Daniela Zanotti, Gabriela Ivanova, Charles Solomon, Xu Dong Yang, Tolulope Balogun, Nicole Staudt, Wei Li, Fatin Al-Janabi, Tom R. Webb, David G. McVey, Nicholas Morrell, Martin Bennett, Nilesh J. Samani, Stefan Gräf, Shu Ye, Nicola Pirastu, Nicole Soranzo, Mattia FrontinibioRxiv 2025.11.10.687750; doi: https://doi.org/10.1101/2025.11.10.687750 This dataset represents one component of a larger multi-omic resource. See the main Zenodo record for the complete collection: DOI 10.5281/zenodo.19480929 Files and organisation README.md: definitions of all columns in the summary statistics files RNAseq.tar: archive containing GWAS summary statistics, provided as one gzipped, tab-separated file per autosomal chromosome (22 files total). RNAseq_cis_eQTLs_chr<chromosome>.tsv.gz (e.g. RNAseq_cis_eQTLs_chr1.tsv.gz): each row represents a single variant–trait association, with molecular traits identified by the trait column. Genomic coordinates are based on GRCh38.批量RNA测序数量性状位点（bulk RNA-seq QTL）汇总统计数据 若使用本数据集，请引用该手稿，以公平致谢所有参与研究及其资助方的贡献。 研究概况 本仓库提供了下述研究中产生的批量RNA测序数量性状位点（QTL）全基因组关联分析（GWAS）汇总统计数据的访问权限： 通过内皮与免疫细胞群表征解析心血管疾病的细胞遗传学机制 Stephen Watt, Matiss Ozols, Arianna Landini, Bin Liu, Sodbo Sharapov, Daniela Zanotti, Gabriela Ivanova, Charles Solomon, Xu Dong Yang, Tolulope Balogun, Nicole Staudt, Wei Li, Fatin Al-Janabi, Tom R. Webb, David G. McVey, Nicholas Morrell, Martin Bennett, Nilesh J. Samani, Stefan Gräf, Shu Ye, Nicola Pirastu, Nicole Soranzo, Mattia Frontini bioRxiv 2025.11.10.687750; DOI: https://doi.org/10.1101/2025.11.10.687750 本数据集为大型多组学资源的组成部分之一。完整数据集请参阅主Zenodo记录：DOI 10.5281/zenodo.19480929 文件与数据组织形式 README.md：汇总统计数据文件中所有字段的定义说明 RNAseq.tar：包含GWAS汇总统计数据的归档文件，按常染色体（共22条）分别存储为单份gzip压缩制表符分隔文件（总计22个文件）。 RNAseq_cis_eQTLs_chr<染色体编号>.tsv.gz（例如RNAseq_cis_eQTLs_chr1.tsv.gz）：每行对应一个单一的变异-性状关联，分子性状通过trait字段进行标识。基因组坐标基于GRCh38参考基因组。

搜集汇总

背景与挑战

背景概述

该数据集是一个针对人脐静脉内皮细胞（HUVEC）的批量RNA测序数量性状位点（QTL）汇总统计资源，基于GRCh38基因组版本，旨在支持心血管疾病细胞遗传学研究。它包含GWAS汇总统计数据，以22个按染色体分组的文件提供变异与分子性状的关联信息，总大小为2.4 GB，发布于2026年并采用开放获取许可证。