Small RNA Sequencing of Colorectal Adenoma Patient Plasma

In our study, we generated and sequenced small RNA libraries from blood plasma samples. These samples were obtained from patients undergoing colonoscopy and are balanced for age, sex, and self-identified ancestry. From the sequencing data, we derived small-RNA feature counts and performed an analysis for differential expression between patients with and without colorectal adenoma. We found numerous significant associations, including hsa-miR-335-5p and a RNA fragment of the theoretical transcript, AK126744. The are 822 fastq files in this submission consisting of sequencing replicates and library generation replicates from 240 patient samples. In this set there are 126 samples from "normal" patients with no findings and 114 from patients for whom a colorectal adenoma was found. Also included is a count table after read processing.