Effects of dipeptidyl peptidase-4 (DPP4) inhibition via BI 14332 to hematological variables and the proliferative capability of PBMC (LSmeans ± SE).

aWith first occurrence of serum β-hydroxybutyrate ≥ 1.2 mM cows were treated with BI 14332 (HC-BI) or stayed untreated as control (HC-Con). BI 14332 was applied once a day over a period of 7 days (intravenous, 0.3 mg/kg body weight). Subclinical ketosis was diagnosed on day +3 (1 cow), day +7 (8 cows) or on day +10 (3 cows) after calving.
bThe day of classification (mean ± SD), which was the day with first occurrence of BHB values ≥ 1.2 mM were set as covariate, integrated in the MIXED procedure of SAS [24] with group and time as fixed factors (P ≤0.05; Tukey test). Significant values are shown in bold.
SI, stimulation index (ratio between the fluorescence in the Alamar Blue assay of concanavalin A-stimulated and unstimulated PBMC); LY, lymphocytes; GR, granulocytes; EO, eosinophile granulocytes; HGB, hemoglobin; HCT, hematocrit
Effects of dipeptidyl peptidase-4 (DPP4) inhibition via BI 14332 to hematological variables and the proliferative capability of PBMC (LSmeans ± SE).