Selectivity of PKC inhibitors towards PKC isoforms<sup>a</sup>.

NIAID Data Ecosystem2026-05-02 收录

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药物靶点药理学

数据链接：

https://figshare.com/articles/dataset/Selectivity_of_PKC_inhibitors_towards_PKC_isoforms_sup_a_sup_/28365155 数据链接链接失效反馈

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Selectivity of PKC inhibitors towards PKC isoformsa.

创建时间：

2025-02-06

Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2

药物分子设计

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Inhibition of androgen biosynthesis is clinically effective for treating androgen-responsive prostate cancer. Abiraterone is a clinical first-in-class inhibitor of cytochrome P450 17A1 (CYP17A1) requi

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Crystal structure of AKR1B10 complexed with NADP+

蛋白质晶体

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Crystal structure of AKR1B10 complexed with NADP+ Descriptor: Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Zhang, L, Zheng, X, Chen, S, Zhai, J, H

Protein Data Bank Japan2023-11-08 更新40

Yersinia pestis FabV variant T276G

微生物酶结构

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Yersinia pestis FabV variant T276G Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DIMETHYL SULFOXIDE, ... Authors: Pschibul, A, Kuper, J, HIrschbeck, M

Protein Data Bank Japan2024-01-10 更新40

How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study Using N ‑Myristoyltransferases as a Model System

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A model system of two related enzymes with conserved binding sites, namely N-myristoyltransferase from two different organisms, was studied to decipher the driving forces that lead to selective inhibi

NIAID Data Ecosystem50

PCI-32765 KiNativ -- single dose experiment

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药物靶点结合

The KiNativ assay platform is based on the use of biotinylated acyl phosphates of ATP and ADP that act as probes by reacting with protein kinases on conserved lysine residues in the ATP binding pocket

NIAID Data Ecosystem40

Selectivity of PKC inhibitors towards PKC isoforms<sup>a</sup>.

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