GWAS summary statistics from: Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression

Here, we provide genome-wide summary statistics from our study: Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression (TRD). We studied the genetic architecture of TRD, defined as major depressive disorder (MDD) with adequate antidepressant trial followed by electroconvulsive therapy (ECT), representing a severe subset of TRD cases. The data include results from genome-wide association meta-analyses of TRD risk (2,062 TRD cases vs. 441,037 healthy controls) and treatment resistance within MDD (2,062 TRD cases vs. 38,544 non-TRD cases), encompassing both common variant and copy number variation (CNV) analyses. A file named "md5sum" is provided to enable verification of data integrity.Citation: Xiong Y, Krebs K, Jermy B, Karlsson R, Pasman JA, Nguyen TD, Gong T, Kowalec K, Rück C, Sigström R, Jonsson L, Clements CC, Hörbeck E, Andersson E, Bäckman J; FinnGen; Estonian Biobank Research Team; Ganna A, German J, Sullivan PF, Landén M, Lehto K, Lu Y. Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression. Mol Psychiatry. 2025 Jun 26. doi: 10.1038/s41380-025-03084-z. Epub ahead of print. PMID: 40571737.