Synthesis of 2‘,3‘-Dideoxy-6‘,6‘-difluorocarbocyclic Nucleosides
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资源简介：
2‘,3‘-Dideoxy-6‘,6‘-difluorouracils, a novel series of gem-difluoromethylenated carbocyclic nucleosides, were synthesized from (Z)-but-2-ene-1,4-diol in 14 steps. A notable step was the construction of the carbocyclic ring via ring-closing metathesis and the incorporation of gem-difluoromethylene group by way of silicon-induced Reformatskii−Claisen reaction of chlorodifluoroacetic ester 3.
创建时间：
2004-11-11
