Hypoxia-inducible transcription factors (HIFs) are fundamental to the cellular adaptation to low oxygen levels but how they interact with chromatin and efficiently activate their target genes is uncle
It is becoming increasingly evident that the degradation of nuclear proteins requires nuclear-cytoplasmic trafficking of both the substrate proteins, as well as the E3 ubiquitin-ligases. Here, we show
Transposon (Tn) and gene replacement mutants found to be sensitive (S) or resistant (R) to 20 mM A-NO2- under anaerobic conditions after 24 hr incubation.
