Replication Data for: A concise SAR-analysis of antimicrobial cationic amphipathic barbiturates for an improved activity-toxicity profile

This dataset contains the analytical data of 58 amphipathic, tetrasubstituted barbituric acid derivatives and their synthetic intermediates. The analytical data includes NMR raw data and HRMS, IR and SFC data as PDF files. The barbituric acid derivatives were constructed to be mimics of antimicrobial peptides (AMPs) and were tested for their antimicrobial activity in the study "A concise SAR-analysis of antimicrobial cationic amphipathic barbiturates for an improved activity-toxicity profile". The structure of all compounds can be found in the data files.

本数据集收录了58种两亲性四取代巴比妥酸衍生物及其合成中间体的分析数据。分析数据包括核磁共振（NMR）原始数据、高分辨质谱（HRMS）、红外（IR）和超临界流体色谱（SFC）数据，并以PDF文件形式提供。这些巴比妥酸衍生物被构建为抗菌肽（AMPs）的模拟物，并在研究“一种简化的抗菌阳离子两亲性巴比妥酸的SAR分析，以改善活性-毒性谱”中对其抗菌活性进行了测试。所有化合物的结构信息均可在数据文件中找到。