Volume velocities of regional blood flow (Q) in naïve and anti-VEGF-administered mice.

Note: Literature values are listed for comparison. Nude mice (n = 5) were naïve or administered a single, intravenous bolus dose (10 mg/kg) of the cross-species anti-VEGF antibody [12], B20-4.1, 24 h prior to assay. All values are reported in µL/g/min. Note that the assay method can greatly influence measured values of Q, especially in probe clearance organs.*pt-test.a[3].b[5].c[40].dReflects inability of probe to cross blood-brain barrier.e85Sr-labeled microspheres [15].fOrigin of measurement not specified in literature.gExtrapolated from inulin clearance rates in rat kidney [41].hBronchial flow.iMeasured experimentally by Rb uptake method.jRat data; method not specified [40].