Pharmacodynamic analysis of data obtained from in vitro time-kill studies in artificial medium and adult bovine serum for oxytetracycline (OTC), danofloxacin (DANO) and tulathromycin (TUL) against MmmSC strain B237.

E0 is the difference in log10 (cfu/mL) units after 24 hours compared to the initial titre when no antimicrobial is present, Emax is the maximum antimycoplasmal effect in log10 (cfu/mL) units, EC50 is the twenty-four hour-area under curve:minimum inhibitory concentration ratio (AUC:MIC) of antimicrobial that gives rise to 50% of the maximum response and N is the Hill coefficient. AUC:MIC ratios are provided for mycoplasmastatic activity (MS) and, where appropriate, mycoplasmacidal activity (MC) and virtual mycoplasmal elimination (VME).