RNA interference targets aberrant transcripts with cognate small interfering RNAs, which are derived from double-stranded RNA precursors. Several functional screens have identified Drosophila Blanks a
The RNA-induced silencing complex, comprising Argonaute and guide RNA, mediates RNA interference. Here we report the 3.2 Å crystal structure of Kluyveromyces Argonaute (KpAGO) fortuitously complexed w
P granules are germ-cell-specific cytoplasmic structures containing RNA and protein and required for proper germ cell development in C. elegans. A new P-granule-associated protein, DEPS-1, whose loss
Argonaute proteins lie at the heart of the RNA-Induced Silencing Complex (RISC), wherein they use small RNA guides to recognize targets. Some Argonaute proteins can directly cleave their targets, wher
RNA-seq of hnRNP K-depleted mouse embryonic stem cells RNA-seq was performed on two biological replicates of control- or Hnrnpk siRNA-transfected TT2 ES cells, 72 h post transfection.