Highly Regioselective, Acid-Catalyzed, Three-Component Cascade Reaction for the Synthesis of 2‑aminopyridine-Decorated Imidazo[1,2‑a]pyridine

A highly regioselective acid-catalyzed three-component reaction of 2-aminopyridine and 3-phenylpropiolaldehyde for the construction of imidazo­[1,2-a]­pyridine has been developed. This strategy provides a broad range of substrates and represents an efficient approach to give various 2-aminopyridine-decorated imidazo­[1,2-a]­pyridine in good yields.