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First Protection of a Wide-Rim Tetraamino Calix[4]arene in Opposite Positions

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NIAID Data Ecosystem2026-03-06 收录
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The importance of tetraamino calix[4]arenes as starting materials is distinctly increased by the first versatile protective group for opposite amino functions. Reaction with trityl chloride leads to the 1,3-dialkylated derivative easily isolated in 34% yield; after a first acylation of the remaining amino groups, the trityl residues can be removed by TFA to introduce a second acyl group.

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2007-03-15
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