Stereoselective Construction of Highly Functionalized Azetidines via a [2 + 2]-Cycloaddition
收藏NIAID Data Ecosystem2026-03-06 收录
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资源简介：
A facile stereoselective synthesis of highly functionalized azetidines from a novel [2 + 2]-cycloaddition of 2-aminomalonates to chalcones is reported. The desired four-membered ring construction proceeded via a grind-promoted solvent-free Michael addition and a PhIO/Bu4NI mediated oxidative cyclization and afforded azetidines in moderate to good yields with excellent diastereoselectivities.
创建时间：
2010-06-18
