Adaptive mutations observed in the P2 and P3 regions of EV71:TLLm and EV71:TLLmv viral genomes.

14—Mutations are based on alignment with the reference EV71:BS genome. 15—Numbering of amino acids in the uncleaved polyprotein prior to maturation. 16—Numbering of amino acids in the mature protein. 17—Mutation located in the Ring finger domain of the RNA-dependent RNA Polymerase. 18—Mutation located in the Palm domain of the RNA-dependent RNA Polymerase. 19—Mutation located in the Thumb domain of the RNA-dependent RNA Polymerase.