Data supporting "Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making"

We used genetic and retrograde labeling to target pyramidal tract (PT), intratelencephalic (IT) and corticostriatal projection neurons and measured their cortex-wide activity. Each PyN type drove unique neural dynamics, both at the local and cortex-wide scale. Cortical activity and optogenetic inactivation during an auditory decision task revealed distinct functional roles. All PyNs in parietal cortex were recruited during perception of the auditory stimulus, but, surprisingly, PT neurons had the largest causal role. In frontal cortex, all PyNs were required for accurate choices but showed distinct choice-tuning. Our results reveal that rich, cell-type-specific cortical dynamics shape perceptual decisions. <br> Dataset supporting: Musall, S., Sun, X.R., Mohan, H. et al. Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making. Nat Neurosci (2023). https://doi.org/10.1038/s41593-022-01245-9